VICODIN 5/500MG is a prescription medication composed of hydrocodone and acetaminophen, combining the analgesic properties of these two substances to provide effective pain relief. Hydrocodone, an opioid agonist, works by binding to receptors in the brain and spinal cord, reducing the perception of pain. Acetaminophen enhances the pain-relieving effects of hydrocodone while also acting as a fever reducer.